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The Indianapolis Colts (11-5) and Buffalo Bills (13-3) lock horns in an AFC playoff game Saturday in NFL Wild Card Weekend at 1:05 p.m. ET at Bills Stadium. Below, we preview the Colts-Bills betting odds and lines and make our NFL picks and predictions.

Colts at Bills: Betting odds, spread and lines

Odds via BetMGM; access USA TODAY Sports’ betting odds for a full list. Lines last updated at 4:04 a.m. ET.

Money line: Colts +230 (bet $100 to win $230) Bills -275 (bet $275 to win $100)Against the spread/ATS: Colts +6.5 (-105) Bills -6.5 (-115)Over/Under: 51.5 (O: -105 U: -115)

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Colts at Bills: Game notes

The Colts enter this game having won four of their past five games outright, but they’re 0-3 ATS since their most recent cover in Week 14 in Las Vegas. Indianapolis has also scored at least 24 points in each of its past eight games.Indianapolis has racked up 378.1 total yards of offense per game to rank 10th in the NFL, and they’re 11th in both passing yards (253.3) and rushing yards (124.8) per contest. The Colts rank ninth with 28.2 PPG.Defensively the Colts have been stout, allowing just 332.1 total yards per game to rank eighth in the NFL, and they’re second in rushing defense with 90.5 yards per game allowed. If teams have success against their D, it’s through the air, as they have allowed 241.6 passing yards per game to check in just 20th.Buffalo scored a season-high 56 points in their 30-point win over Miami in Week 17, winning for the sixth straight game, while covering for the eighth consecutive outing. They have also won five straight at home and covered four in a row in Western New York.The Bills’ offense has been on point, going for 396.4 total yards per game to rank second in the NFL. They’re also second in points scored, 31.3 PPG while averaging 288.8 passing yards per game to rank third in the league. If they have an Achilles heel, it’s their run game, which generated just 107.7 rushing yards per contest.

Colts at Bills: Key injuries

Colts

DT DeForest Buckner (ankle) questionableCB Rock Ya-Sin (concussion) out

Bills

WR Cole Beasley (knee) questionableWR Stefon Diggs (oblique) questionable

Nfl Betting Tips Week 2

Colts at Bills: Odds, betting lines, predictions and picks

Prediction

Bills 29, Colts 20

Money line (?)

Playing the Bills (-275) is not a good idea, risking nearly three times your potential return. Over the long haul, it’s a losing proposition to bet in that manner unless you plan to toss it into a multi-team parlay. Even then, it’s better to just bet against the spread. PASS.

Against the spread (?)

The BILLS -6.5 (-115) have been money at home, with their last non-cover coming in Week 8 against New England in a 24-21 win as four-point favorites, and their last outright loss coming in Week 10 against the Arizona Cardinals on the Hail Murray, 32-30.

Even without their throngs of fans at full throat, Bills Stadium has been a difficult place to play. They’ll have a limited amount of fans in the stands Saturday to help spur them on.

Over/Under (?)

These are a couple of high-flying offenses, and they should put on a show in the opening game of the 2020 NFL playoffs. However, the lean is to the UNDER 51.5 (-115).

In last season’s wild-card round the Under was a perfect 4-0, and the Under is hitting at a 75.8 percent clip (22-7-3) across the wild-card round in the past eight seasons. That’s good enough for me to keep banging Under plays.

Want action on this NFL game? Sign up and bet at BetMGM. If you’re looking for more sports betting picks and tips, visit SportsbookWire.com. Please gamble responsibly.

Also see:

Bet Slippin’ PodcastColts’ Ryan Kelly, Luke Rhodes named second-team All-Pro (Colts Wire)Bills vs. Colts: 3 key matchups in Wild Card (Bills Wire)

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